Title: Synthesis of a new branched-chain hexopyranosyl nucleoside - 1-[2',3'-dideoxy-3'-C-(hydroxymethyl)-alpha-D-erythro-pentopyranosyl]-thymine
Authors: Augustyns, K ×
Rozenski, Jef
Van Aerschot, Arthur
Busson, Roger
Claes, Paul
Herdewijn, Piet #
Issue Date: 1994
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:50 issue:4 pages:1189-1198
Abstract: A straightforward synthesis of the branched chain nucleoside 7 is described. This synthesis involves two stereoselective steps : introduction of the hydroxymethyl group on the sugar is achieved by radical cyclization of the (bromomethyl)dimethylsilyl ether of the allylic alcohol 8; the condensation reaction with thymine as base moiety resulted exclusively in the formation of the alpha anomer.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Formal and Computational Linguistics (ComForT), Leuven
× corresponding author
# (joint) last author

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