Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Verhelst, Johan; Velkeniers, Brigitte; Maiter, Dominique; Haentjens, Patrick; T'Sjoen, Guy; Rietzschel, Ernst; Corvilain, Bernard; Abrams, Pascale; Nobels, Frank; Abs, Roger; Bex, Mieke

doi:10.1530/EJE-12-0753

Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Author:

Verhelst, Johan

Velkeniers, Brigitte ; Maiter, Dominique ; Haentjens, Patrick ; T'Sjoen, Guy ; Rietzschel, Ernst ; Corvilain, Bernard ; Abrams, Pascale ; Nobels, Frank ; Abs, Roger ; Bex, Mieke

Keywords:

Acromegaly, Adult, Aged, Belgium, Blood Pressure, Body Mass Index, C-Reactive Protein, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Prognosis, Registries, Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, CARDIOVASCULAR RISK-FACTORS, BRAIN NATRIURETIC PEPTIDE, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, GROWTH-FACTOR-I, IGF-I, RECEPTOR ANTAGONIST, DEFICIENT PATIENTS, CARDIAC-FUNCTION, HORMONE, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences, 3215 Reproductive medicine

Abstract:

Patients with active acromegaly have an increased prevalence of cardiomyopathy and heart failure but a less than expected risk of coronary artery disease, considering the frequent association of diabetes mellitus and hypertension. We examined whether changes in high-sensitive C-reactive protein (hs-CRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) might contribute to this phenomenon.