Title: Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study
Authors: Teughels, Wim * ×
Durukan, Andaç *
Ozcelik, Onur
Pauwels, Martine
Quirynen, Marc
Haytac, Mehmet Cenk #
Issue Date: 2013
Publisher: Munksgaard
Series Title: Journal of Clinical Periodontology vol:40 issue:11 pages:1025-1035
Abstract: Aim: The aim of this randomized placebo-controlled clinical trial was to evaluate
the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to
scaling and root planing (SRP).
Material and Methods: Thirty chronic periodontitis patients were recruited and
monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after
therapy. All patients received one-stage full-mouth disinfection and randomly
assigned over a test (SRP + probiotic, n = 15) or control (SRP + placebo, n = 15)
group. The lozenges were used two times a day for 12 weeks.
Results: At week 12, all clinical parameters were significantly reduced in both
groups, while there was significantly more pocket depth reduction (p < 0.05) and
attachment gain (p < 0.05) in moderate and deep pockets; more Porphyromonas
gingivalis reduction was observed in the SRP + probiotic group.
Conclusions: The results indicate that oral administration of L. reuteri lozenges
could be a useful adjunct to SRP in chronic periodontitis.
ISSN: 0303-6979
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Periodontology
* (joint) first author
× corresponding author
# (joint) last author

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