Title: Isocratic separation of erythromycin, related substances and degradation products by liquid chromatography on XTerra RP18
Authors: Chepkwony, HK ×
Dehouck, Pieter
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Feb-2001
Publisher: Vieweg
Series Title: Chromatographia vol:53 issue:3-4 pages:159-165
Abstract: A simple, sensitive, selective and robust isocratic LC method is described for the analysis of erythromycin on XTerra RP18 The main component, erythromycin A is separated from all known related substances and degradation products. Several unknown impurities are also separated. Acetonitrile - 0.2 M K2HPO4 pH 7.0 - water,(35:5:60, v/v) was used as a mobile phase at 1.0 mL min(-1). UV detection was at 215 nm. The robustness of the method was evaluated by a full-factorial experimental design.
ISSN: 0009-5893
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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