Title: Rapamycin increases survival in ALS mice lacking mature lymphocytes
Authors: Staats, Kim A
Hernandez, Sara
Schönefeldt, Susann
Abreu Bento, André
Dooley, James
Van Damme, Philip
Liston, Adrian
Robberecht, Wim
Van Den Bosch, Ludo # ×
Issue Date: Sep-2013
Series Title: Molecular Neurodegeneration vol:8
Article number: 31
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. Disease pathophysiology is complex and not yet fully understood, but is proposed to include the accumulation of misfolded proteins, as aggregates are present in spinal cords from ALS patients and in ALS model organisms. Increasing autophagy is hypothesized to be protective in ALS as it removes these aggregates. Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated.
ISSN: 1750-1326
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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