Nucleosides & Nucleotides
Publication date:
1998-01-01
Volume:
17
Pages:
1523 -
1526
Publisher:
M. Dekker
Author:
Allart, B
Van Aerschot, Arthur ; Herdewijn, Piet
Keywords:
nucleosides, 0601 Biochemistry and Cell Biology, Organic Chemistry, 3101 Biochemistry and cell biology, 3404 Medicinal and biomolecular chemistry
Abstract:
As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blacks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (a(h)U)(13)/(dA)(13) duplex.