Title: 1,5-anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA
Authors: Allart, B ×
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 1998
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:17 issue:9-11 pages:1523-1526
Abstract: As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blacks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (a(h)U)(13)/(dA)(13) duplex.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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