Title: 3'-amidated 3'-deoxyxylofuranose analogues of N-6-cyclopentyladenosines: A new class of non-xanthine antagonists at the adenosine A(1) receptor
Authors: Van Calenbergh, S ×
IJzerman, AP
Herdewijn, Piet #
Issue Date: 1998
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:17 issue:9-11 pages:1571-1576
Abstract: Full adenosine A(1) receptor agonists like CPA and other N-6-substituted adenosine analogs have previously been shown to become partial agonists upon deletion of the 3'-hydroxyl moiety. The present study further explored the C-3' site for modification. The modest affinity at A(1) and A(2a) receptors found in the 3'-amido-3'-deoxyxylofuranosyladenine series prompted us to synthesize the corresponding N-6-cyclopentyl derivatives, which proved to exhibit potent antagonistic behaviour at the A(1) receptors. This represents a new perspective in the purinergic field.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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