Title: Divers stereoisomers of N-acetylhydroxyprolinol as sugar substitute in oligonucleotides
Authors: Ceulemans, G
Van Aerschot, Arthur
Herdewijn, Piet # ×
Issue Date: 1998
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:17 issue:9-11 pages:1577-1581
Abstract: A detailed comparison of the hybridisation characteristics of oligonucleotides with 4-hydroxy-N-acetylprolinol or 3-hydroxy-N-acerylprolinol as sugar substitute, reveals dramatic differences. The 4-HO oligonucleotides are able to form stable complexes which are in general duplexes when natural nucleic acids are used as the complement, and the system has a strong preference for isochiral interaction. For the 3-HO oligonucleotides on the other hand complexes are generally weak, triple stranded, and often isochiral and heterochiral hybrids have a similar stability.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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