Title: Identification and characterization of histatin 1 salivary complexes by using mass spectrometry
Authors: Siqueira, Walter L ×
Lee, Young Ho
Xiao, Yizhi
Held, Kathi
Wong, Williston #
Issue Date: Nov-2012
Publisher: WILEY-VCH Verlag
Series Title: Proteomics vol:12 issue:22 pages:3426-35
Article number: 10.1002/pmic.201100665
Abstract: With recent progress in the analysis of the salivary proteome, the number of salivary proteins identified has increased dramatically. However, the physiological functions of many of the newly discovered proteins remain unclear. Closely related to the study of a protein's function is the identification of its interaction partners. We investigated interactions among and functions of histatin 1 and the other proteins that are present in saliva by using high-throughput mass spectrometric techniques. This led to the identification of 43 proteins able to interact with histatin 1. In addition, we found that these protein-protein interactions protect complex partners from proteolysis and modulate their antifungal activity. Our data contribute significantly to characterization of the salivary interactome and to understanding the biology of salivary protein complexes.
ISSN: 1615-9853
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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