Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Wouters, Mira; Lambrechts, Diether; Knapp, Michael; Cleynen, Isabelle; Whorwell, Peter; Agréus, Lars; Dlugosz, Aldona; Schmidt, Peter Thelin; Halfvarson, Jonas; Simrén, Magnus; Ohlsson, Bodil; Karling, Pontus; van Wanrooy, Sander; Mondelaers, Stéphanie; Vermeire, Severine; Lindberg, Greger; Spiller, Robin; Dukes, George; D'Amato, Mauro; Boeckxstaens, Guy

doi:10.1136/gutjnl-2013-304570

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Author:

Wouters, Mira

Lambrechts, Diether ; Knapp, Michael ; Cleynen, Isabelle ; Whorwell, Peter ; Agréus, Lars ; Dlugosz, Aldona ; Schmidt, Peter Thelin ; Halfvarson, Jonas ; Simrén, Magnus ; Ohlsson, Bodil ; Karling, Pontus ; van Wanrooy, Sander ; Mondelaers, Stéphanie ; Vermeire, Severine ; Lindberg, Greger ; Spiller, Robin ; Dukes, George ; D'Amato, Mauro ; Boeckxstaens, Guy

Keywords:

Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, FAMILIAL AGGREGATION, ASSOCIATION, POLYMORPHISMS, PERMEABILITY, INFLAMMATION, PATHOGENESIS, EXPRESSION, ANXIETY, TWINS, GENETIC POLYMORPHISMS, IMMUNE RESPONSE, Adult, Case-Control Studies, Cohort Studies, Constipation, Diarrhea, Female, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Genotyping Techniques, Glycoproteins, Humans, Irritable Bowel Syndrome, Male, Middle Aged, Neuropeptides, Polymorphism, Single Nucleotide, cdc42 GTP-Binding Protein, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences, 3210 Nutrition and dietetics

Abstract:

The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS.