Title: Carbohydrates as chiral selectors for capillary electrophoresis of racemic drugs
Authors: DHulst, A ×
Verbeke, Norbert #
Issue Date: 1997
Publisher: Gordon breach sci publ ltd
Series Title: Enantiomer vol:2 issue:1 pages:69-79
Abstract: Maltodextrins, complex mixtures of linear analogues of cyclodextrins, were studied as chiral electrolyte additives in CE and found to provide highly efficient chiral separations of a broad range of acidic and basic compounds. Although the carbohydrate used is the major determinant in obtaining enantioseparation, further optimization through variation of secondary parameters, e.g. the composition of the background electrolyte or the capillary dimensions, is shown to be possible. The introduction of additional elements of chirality through the buffer component or via secondary chiral polymeric electrolyte modifiers were shown to affect selectivity as well as efficiency, leading to a significant improvement of separation in some instances, while in other conditions comigration of enantiomers was observed, suggesting multiple chiral recognition mechanisms may not proceed independently from one another.
ISSN: 1024-2430
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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