Title: Oligonucleotides with 2,6-diaiminopurine base replacing for adenine: Synthesis and properties
Authors: Boudou, V ×
Rothenbacher, K
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 1999
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:18 issue:6-7 pages:1429-1431
Abstract: Synthesis of three nucleoside building blocks with a benzoyl protected diaminopurine (DAP) base and their incorporation at different positions of DNA, RNA and hexitol oligomers (HNA) have been accomplished. DNA hairpins with a DAP substituted for one (or more) adenine in the loop structure were not found to be more stable. But the stability of RNA-hexitol as well as hexitol-hexitol duplexes improved when the adenine base was replaced with DAP.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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