Title: Synthesis of 2'-deoxy-2'-fluoro-D-arabinopyranosyl nucleosides and their 3',4'-seco analogs
Authors: Herdewijn, Piet ×
Van Aerschot, Arthur
Busson, Roger
Claes, Paul
De Clercq, Erik #
Issue Date: 1991
Publisher: Marcel dekker inc
Series Title: Nucleosides & nucleotides vol:10 issue:7 pages:1525-1549
Abstract: 2'-Deoxy-2'-fluoro-D-arabinopyranosyl nucleosides were synthesized by condensation of 1,3,4-tri-O-benzoyl-2-deoxy-2-fluoro-D-arabinopyranose with the appropriate silylated bases in the presence of trimethylsilyl triflate. Scission of the 3',4'-bond by periodate oxidation followed by sodium borohydride reduction resulted in the formation of the 3',4'-seco analogues of the 2'-deoxy-2'-fluoro-D-arabinofuranosyl nucleosides.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Formal and Computational Linguistics (ComForT), Leuven
Cell Metabolism
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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