Title: Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice
Authors: Bot, Martine ×
Van Veldhoven, Paul P
de Jager, Saskia C A
Johnson, Jason
Nijstad, Niels
Van Santbrink, Peter J
Westra, Marijke M
Van der Hoeven, Gerd
Gijbels, Marion J
Müller-Tidow, Carsten
Varga, Georg
Tietge, Uwe J F
Kuiper, Johan
Van Berkel, Theo J C
Nofer, Jerzy-Roch
Bot, Ilze
Biessen, Erik A L #
Issue Date: 2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:5 pages:e63360
Article number: 10.1371/journal.pone.0063360
Abstract: Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(-/-)) deficiency on leukocyte subsets relevant to atherosclerosis.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Lipid Biochemistry and Protein Interactions
Laboratory of Biosignaling & Therapeutics
× corresponding author
# (joint) last author

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