Title: Autophagy: shaping the tumor microenvironment and therapeutic response
Authors: Maes, Hannelore
Rubio, Noemí
GARG, Abhishek
Agostinis, Patrizia # ×
Issue Date: Jul-2013
Publisher: Elsevier Science Ltd.
Series Title: Trends in Molecular Medicine vol:19 issue:7 pages:428-46
Article number: 10.1016/j.molmed.2013.04.005
Abstract: Autophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, is emerging as a key process modulating tumorigenesis, tumor-stroma interactions, and cancer therapy. Research over the past decade has highlighted a context-dependent and dynamic role for autophagy in cancer: it is tumor suppressive in the early stages of cancer development, but fuels the growth of established tumors. Likewise, the stimulation of autophagy in response to therapeutics can contextually favor or weaken chemoresistance and antitumor immunity. From a therapeutic perspective, understanding whether, when, and how autophagy can be harnessed to kill cancer cells remains challenging. In this review, we discuss new connections that reveal the role of autophagy in shaping tumor-stroma interaction during carcinogenesis and in the context of anticancer treatments.
ISSN: 1471-4914
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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