Title: Capillary electrophoretic analysis of ethylene dicysteine, a precursor of the radiopharmaceutical Tc-99m ethylene dicysteine
Authors: Van Schepdael, Ann ×
Verbeke, Kristin
Van Nerom, C
Hoogmartens, Jos
Verbruggen, Alfons #
Issue Date: Dec-1997
Publisher: Elsevier
Series Title: Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences vol:697 issue:1-2 pages:251-254
Abstract: L,L-Ethylene dicysteine (EC) is a ligand used in nuclear medicine for the preparation of Tc-99m-L,L-EC, a tracer agent for renal function studies. A capillary zone electrophoretic method is described which allows us to monitor the purity of ethylene dicysteine, for which no other suitable method has been reported to date. A fused-silica capillary (L=70 cm, l=62 cm, 75 mu m I.D.) was used with 10 mM sodium tetraborate, pK 10.0, as the background electrolyte. The voltage applied was 20 kV and the temperature was 25 degrees C. Benzyl alcohol served as the internal standard. The limit of detection was 0.07% and the limit of quantitation was 0.15%. (C) 1997 Elsevier Science B.V.
ISSN: 1570-0232
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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