Title: Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Authors: Dehouck, Pieter
Vander Heyden, Y
Smeyers-Verbeke, J
Massart, DL
Crommen, J
Hubert, P
Marini, RD
Smeets, OSNM
Decristoforo, G
Van de Wauw, W
De Beer, J
Quaglia, MG
Stella, C
Veuthey, JL
Estevenon, O
Van Schepdael, Ann
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Apr-2003
Publisher: Elsevier science bv
Series Title: Analytica chimica acta vol:481 issue:2 pages:261-272
Abstract: The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst,is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl-Fischer water determination, an acid-base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s(r)(2) and s(L)(2) as estimates of the repeatability variance (sigma(r)(2)) and the between-laboratory variance (sigma(L)(2)), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates. (C) 2003 Elsevier Science B.V. All rights reserved.
ISSN: 0003-2670
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
# (joint) last author

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