Nuclear Medicine and Biology vol:27 issue:8 pages:781-789
L-Cysteine acetyldiglycine (L-CAG2), a hybrid compound of L,L-EC and MAG3, and its L P-homocysteine analogue L-HAG2 were synthesized. After labeling with Tc-99m, Tc-99m-L-CAG2 and Tc-99m-L-HAG2 gave two peaks on high performance liquid chromatography. Urinary excretion of both isomers of Tc-99m-L-CAG2 and Tc-99m L-HAG2 was slower than for the "parent" complexes Tc-99m MAG3 or (TC)-T-99m-L,L-EC. Isomer B of Tc-99m-L-CAG2 showed pronounced kidney retention in mice (57% of ID in kidneys at 30 min postinjection), but further evaluation in baboon did not reproduce this phenomenon. NUCL MED BIOL 27;8:781-789, 2000. (C) 2000 Elsevier Science Inc, All rights reserved.