Title: Synthesis and evaluation of the Tc-99m-complexes of L-cysteine acetyldiglycine (a hybrid of MAG3 and L,L-EC) and of L-beta-homocysteine acetyldiglycine
Authors: Mang'era, K ×
Vanbilloen, H
Cleynhens, Bernard
de Groot, Tjibbe
Bormans, Guy
Verbruggen, Alfons
Verbeke, Kristin #
Issue Date: Nov-2000
Publisher: Pergamon Press
Series Title: Nuclear Medicine and Biology vol:27 issue:8 pages:781-789
Abstract: L-Cysteine acetyldiglycine (L-CAG2), a hybrid compound of L,L-EC and MAG3, and its L P-homocysteine analogue L-HAG2 were synthesized. After labeling with Tc-99m, Tc-99m-L-CAG2 and Tc-99m-L-HAG2 gave two peaks on high performance liquid chromatography. Urinary excretion of both isomers of Tc-99m-L-CAG2 and Tc-99m L-HAG2 was slower than for the "parent" complexes Tc-99m MAG3 or (TC)-T-99m-L,L-EC. Isomer B of Tc-99m-L-CAG2 showed pronounced kidney retention in mice (57% of ID in kidneys at 30 min postinjection), but further evaluation in baboon did not reproduce this phenomenon. NUCL MED BIOL 27;8:781-789, 2000. (C) 2000 Elsevier Science Inc, All rights reserved.
ISSN: 0969-8051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Translational Research in GastroIntestinal Disorders
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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