Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer
Loi, Sherene × Michiels, Stefan Lambrechts, Diether Fumagalli, Debora Claes, Bart Kellokumpu-Lehtinen, Pirkko-Liisa Bono, Petri Kataja, Vesa Piccart, Martine J Joensuu, Heikki Sotiriou, Christos #
Oxford University Press
Journal of the National Cancer Institute vol:105 issue:13 pages:960-7
Certain somatic alterations in breast cancer can define prognosis and response to therapy. This study investigated the frequencies, prognostic effects, and predictive effects of known cancer somatic mutations using a randomized, adjuvant, phase III clinical trial dataset.