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Title: Synthesis and biological evaluation of 23-oxa-24-oxo-1-alpha,25-dihydroxyvitamin-d3, 23-thia-24-oxo-1-alpha,25-dihydroxyvitamin-d3 and 23-oxa-24-oxo-1-alpha,25-dihydroxyvitamin-d3
Authors: Allewaert, K
Vanbaelen, H
Bouillon, Roger
Zhao, Xy
Declercq, P
Vandewalle, M #
Issue Date: Sep-1993
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:3 issue:9 pages:1859-1862
Abstract: The synthesis includes the side-chain construction starting from the Inhoffen-Lythgoe diol and coupling with the A ring. Both 23-oxa- and 23-thia-analogues showed a decreased cell differentiating effect but even a more decreased calcemic effect compared with 1alpha,25-(OH)2D3.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
# (joint) last author

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