Title: Synthesis and biological evaluation of some 25,26-epoxy-1-alpha,24-dihydroxyvitamin-d3 analogs
Authors: Zhao, Xy
Declercq, P
Vandewalle, M
Allewaert, K
Vanbaelen, H
Bouillon, Roger #
Issue Date: 1993
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:3 issue:9 pages:1863-1867
Abstract: The synthesis of all stereoisomeric 25,26-epoxy-1alpha,24-dihydroxyvitamin D3 analogues is described and relies on the Sharpless kinetic resolution of secondary alcohols. It further includes the Julia procedure for side chain construction and the Lythgoe A-ring coupling procedure. Biological evaluation includes the study of calcemic effect, receptor binding and cell differentiation.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Faculty of Pharmaceutical Sciences - miscellaneous
# (joint) last author

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