Title: Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels
Authors: Jin, Rong ×
Moreira Teixeira, Liliana
Dijkstra, Pieter J
van Blitterswijk, Clemens A
Karperien, Marcel
Feijen, Jan #
Issue Date: May-2011
Publisher: Elsevier Science Publishers
Series Title: Journal of Controlled Release vol:152 issue:1 pages:186-95
Article number: 10.1016/j.jconrel.2011.01.031
Abstract: In this study, injectable hydrogels were prepared by horseradish peroxidase-mediated co-crosslinking of dextran-tyramine (Dex-TA) and heparin-tyramine (Hep-TA) conjugates and used as scaffolds for cartilage tissue engineering. The swelling and mechanical properties of these hydrogels can be easily controlled by the Dex-TA/Hep-TA weight ratio. When chondrocytes were incorporated in these gels, cell viability and proliferation were highest for gels with a 50/50 weight ratio of Dex-TA/Hep-TA. Moreover, these hydrogels induced an enhanced production of chondroitin sulfate and a more abundant presence of collagen as compared to Dex-TA hydrogels. The results indicate that injectable Dex-TA/Hep-TA hydrogels are promising scaffolds for cartilage regeneration.
ISSN: 0168-3659
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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