Title: Central precocious puberty caused by mutations in the imprinted gene MKRN3
Authors: Abreu, Ana Paula ×
Dauber, Andrew
Macedo, Delanie B
Noel, Sekoni D
Brito, Vinicius N
Gill, John C
Cukier, Priscilla
Thompson, Iain R
Navarro, Victor M
Gagliardi, Priscila C
Rodrigues, Tânia
Kochi, Cristiane
Longui, Carlos Alberto
Beckers, Dominique
de Zegher, Francis
Montenegro, Luciana R
Mendonca, Berenice B
Carroll, Rona S
Hirschhorn, Joel N
Latronico, Ana Claudia
Kaiser, Ursula B #
Issue Date: Jun-2013
Series Title: New England Journal of Medicine vol:368 issue:26 pages:2467-75
Article number: 10.1056/NEJMoa1302160
Abstract: The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic-pituitary-gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factors, but only a few, rare molecular defects associated with central precocious puberty have been identified.
ISSN: 0028-4793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

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