Title: Anaplastic lymphoma kinase in human cancer
Authors: Barreca, Antonella ×
Lasorsa, Elena
Riera, Ludovica
Machiorlatti, Rodolfo
Piva, Roberto
Ponzoni, Maurilio
Kwee, Ivo
Bertoni, Francesco
Piccaluga, Pier Paolo
Pileri, Stefano A
Inghirami, Giorgio
Tousseyn, Thomas
European T-Cell Lymphoma Study Group #
Issue Date: Aug-2011
Publisher: Journal of Endocrinology (Ltd. by Guarantee)
Series Title: Journal of Molecular Endocrinology vol:47 issue:1 pages:R11-23
Article number: 10.1530/JME-11-0004
Abstract: The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.
ISSN: 0952-5041
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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