Title: Long-Term miR-669a Therapy Alleviates Chronic Dilated Cardiomyopathy in Dystrophic Mice
Authors: Quattrocelli, Mattia ×
Crippa, Stefania
Montecchiani, Celeste
Camps, Jordi
Cornaglia, Antonia Icaro
Boldrin, Luisa
Morgan, Jennifer
Calligaro, Alberto
Casasco, Andrea
Orlacchio, Aldo
Gijsbers, Rik
D'hooge, Jan
Toelen, Jaan
Janssens, Stefan
Sampaolesi, Maurilio #
Issue Date: 2013
Publisher: Wiley-Blackwell Publishing, Inc.
Series Title: Journal of the American Heart Association. Cardiovascular and Cerebrovascular Disease vol:2 issue:4 pages:e000284
Article number: 10.1161/JAHA.113.000284
Abstract: Dilated cardiomyopathy (DCM) is a leading cause of chronic morbidity and mortality in muscular dystrophy (MD) patients. Current pharmacological treatments are not yet able to counteract chronic myocardial wastage, thus novel therapies are being intensely explored. MicroRNAs have been implicated as fine regulators of cardiomyopathic progression. Previously, miR-669a downregulation has been linked to the severe DCM progression displayed by Sgcb-null dystrophic mice. However, the impact of long-term overexpression of miR-669a on muscle structure and functionality of the dystrophic heart is yet unknown.
ISSN: 2047-9980
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Interdepartemental Stem Cell Institute (-)
Stem Cell Biology and Embryology (+)
× corresponding author
# (joint) last author

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