Title: Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity
Authors: Costamagna, Domiziana *
Quattrocelli, Mattia *
Duelen, Robin
Sahakyan, Vardine
Perini, Ilaria
Palazzolo, Giacomo
Sampaolesi, Maurilio # ×
Issue Date: Feb-2014
Publisher: Birkhäuser Verlag
Series Title: Cellular and Molecular Life Sciences vol:71 issue:4 pages:615-27
Abstract: Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
ISSN: 1420-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Embryo and Stemcells (-)
Stem Cell Biology and Embryology (+)
* (joint) first author
× corresponding author
# (joint) last author

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