Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization
Menoret, Delphine × Santolini, Marc Fernandes, Isabelle Spokony, Rebecca Zanet, Jennifer Gonzalez, Ignacio Latapie, Yvan Ferrer, Pierre Rouault, Herve White, Kevin P Besse, Philippe Hakim, Vincent Aerts, Stein Payre, Francois Plaza, Serge #
BioMed Central Ltd.
Genome Biology vol:23 issue:14
Developmental programs are implemented by regulatory interactions between Transcription Factors (TFs) and their target genes, which remain poorly understood. While recent studies have focused on regulatory cascades of TFs that govern early development, little is known about how the ultimate effectors of cell differentiation are selected and controlled. We addressed this question during late Drosophila embryogenesis, when the finely tuned expression of the TF Ovo/Shavenbaby (Svb) triggers the morphological differentiation of epidermal trichomes.