Title: Delivery of antisense oligonucleotides using cholesterol modified sense dendrimers and cationic lipids
Authors: Chaltin, Patrick
Margineanu, Anca
Marchand, Damien
Van Aerschot, Arthur
Rozenski, Jef
De Schryver, Frans
Hermann, A
Müllen, K
Juliano, R
Fisher, MH
Kang, HM
De Feyter, Steven
Herdewijn, Piet # ×
Issue Date: Jul-2005
Publisher: American Chemical Society
Series Title: Bioconjugate Chemistry vol:16 issue:4 pages:827-836
Abstract: Cholesterol modified mono-, di-, and tetrameric oligonucleotides were synthesized and hybridized with antisense oligonucleotides to study their incorporation in cationic liposomes together with the influence of this dendrimeric delivery system on biological activity. Electrostatic interactions seem to play the most important role during complexation with cationic lipids. This oligonucleotide formulation gives a small but significant increase in the inhibition of P-glycoprotein expression in a cellular system.
ISSN: 1043-1802
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
KU Leuven Research & Development (LRD) Central - miscellaneous (-)
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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