Title: LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
Authors: Maier, Wladislaw
Bednorz, Mariola
Meister, Sabrina
Roebroek, Anton
Weggen, Sascha
Schmitt, Ulrich
Pietrzik, Claus U # ×
Issue Date: Jul-2013
Series Title: Molecular Neurodegeneration vol:8 pages:25
Article number: 10.1186/1750-1326-8-25
Abstract: The N-methyl-D-aspartate receptors are key mediators of excitatory transmission and are implicated in many forms of synaptic plasticity. These receptors are heterotetrameres consisting of two obligatory NR1 and two regulatory subunits, usually NR2A or NR2B. The NR2B subunits are abundant in the early postnatal brain, while the NR2A/NR2B ratio increases during early postnatal development. This shift is driven by NMDA receptor activity. A functional interplay of the Low Density Lipoprotein Receptor Related Protein 1 (LRP1) NMDA receptor has already been reported. Such abilities as interaction of LRP1 with NMDA receptor subunits or its important role in tPa-mediated NMDA receptor signaling were already demonstrated. Moreover, mice harboring a conditional neuronal knock-out mutation of the entire Lrp1 gene display NMDA-associated behavioral changes. However, the exact role of LRP1 on NMDA receptor function remains still elusive.
ISSN: 1750-1326
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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