Title: Quantitative analysis of sorbic acid in pharmaceutical cream formulations by liquid chromatography on poly(styrene-divinylbenzene)
Authors: AluochOrwa, J ×
Quintens, I
Roets, Eugene
Hoogmartens, Jos #
Issue Date: May-1997
Publisher: Elsevier science bv
Series Title: European journal of pharmaceutical sciences vol:5 issue:3 pages:155-161
Abstract: A method is described for quantitative analysis of sorbic acid in fat soluble cream formulations. A poly(styrene-divinylbenzene) column (PLRP-S 8 mu m 100 Angstrom, 250x4.6 mm I.D.), maintained at 60 degrees C was used. The mobile phase was acetonitrile-0.2 M phosphate buffer (pH 7.0)-water (1:5:94, v/v/v). The flow-rate was 1.0 ml min(-1) and UV detection was performed at 254 nm. Sample preparation was carried out by treatment of the cream formulations with a mixture of hexane and mobile phase. The method showed good repeatability, linearity and recovery. It was observed that in most of the creams examined the stability of sorbic acid was poor.
ISSN: 0928-0987
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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