Title: Synthesis and biological evaluation of (68)Ga-bis-DOTA-PA as a potential agent for positron emission tomography imaging of necrosis
Authors: Prinsen, Kristof
Cona, Marlein M
Cleynhens, Bernard J
Li, Junjie
Vanbilloen, Hubert
Dyubankova, Natalia
Lescrinier, Eveline
Ni, Yicheng
Bormans, Guy
Verbruggen, Alfons # ×
Issue Date: Aug-2013
Publisher: Pergamon Press
Series Title: Nuclear Medicine and Biology vol:40 issue:6 pages:816-822
Article number: 10.1016/j.nucmedbio.2013.04.011
Abstract: Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment. A radiotracer that could image necrotic cell death using PET could therefore be a useful tool to provide relevant information on the disease activity or therapeutic efficacy and assist in diagnosis and therapy management of several disorders. Pamoic acid derivatives have previously been reported to show a selective uptake in tissue undergoing cellular death via necrosis. In this study 4,4'-methylene-bis(2-hydroxy-3-naphthoic hydrazide) (pamoic acid bis-hydrazide) was conjugated to the macrocyclic ligand DOTA and labeled with the generator produced positron emitter (68)Ga. The resulting complex ((68)Ga-bis-DOTA-PA; (68)Ga-3) was evaluated as a potential radiotracer for imaging tissues undergoing cellular death via necrosis.
ISSN: 0969-8051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Radiopharmaceutical Research
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science