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Angewandte Chemie - International Edition

Publication date: 2013-07-01
Volume: 52 Pages: 8139 - 8143
Publisher: Wiley-VCH

Author:

Pezo, Valérie
Liu, Feng Wu ; Abramov, Mikhail ; Froeyen, Mathy ; Herdewijn, Piet ; Marlière, Philippe

Keywords:

XNA - 320683;info:eu-repo/grantAgreement/EC/FP7/320683, Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, gene expression, hypoxanthine, nucleic acids, thymidylate synthetase, uracil, BUILDING-BLOCKS, NUCLEIC-ACIDS, OLIGONUCLEOTIDES, REPLICATION, RECOGNITION, NUCLEOSIDE, Arabinose, Base Sequence, Catalytic Domain, Cyclohexenes, DNA, Escherichia coli, Escherichia coli Proteins, Hypoxanthine, Nucleotides, Sugar Alcohols, Thymidylate Synthase, Xenobiotics, 03 Chemical Sciences, Organic Chemistry, 34 Chemical sciences

Abstract:

Hereditary information, coded in two bases, can be conveyed to DNA in vivo in the form of cyclohexenyl nucleic acid (CeNA), arabinofuranosyl nucleic acid (AraNA), and hexitol nucleic acid (HNA) messages. It was thus demonstrated that a binary genetic cassette can be used for the title process.