Title: Synthesis of Phosphonoglycine Backbone Units for the Development of Phosphono Peptide Nucleic Acids
Authors: Doboszewski, Bogdan
Groaz, Elisabetta
Herdewijn, Piet # ×
Issue Date: Aug-2013
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:22 pages:3804-4815
Abstract: A series of phosphono-modified backbone mimics based on achiral and chiral N-(dihydroxypropyl)glycine units were obtained by sequential addition of phosphonate and nucleobase moieties to suitably protected dihydroxypropylamines. Simple synthetic strategies enabled the preparation of various target derivatives that will be useful as building blocks for the preparation of new synthetic polymers containing a phosphonate internucleotide linkage in place of the standard phosphodiester bond.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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