Genetic characterization of a rare bovine-like human VP4 mono-reassortant G6P rotavirus strain detected from an infant in Bangladesh
Afrad, Mokibul Hassan × Matthijnssens, Jelle Moni, Sayra Kabir, Farzana Ashrafi, Adnin Rahman, Mohammed Ziaur Faruque, Abu S G Azim, Tasnim Rahman, Mustafizur #
Infection, Genetics and Evolution vol:19 pages:120-126
During an ongoing diarrhea etiology surveillance in Mirzapur, Bangladesh, a rare human G6P RVA strain (RVA/Human-wt/BGD/KH2288/2011/G6P) was detected in a stool sample of a 7-month-old infant with acute diarrhea. Complete genotype analyses revealed that KH2288 possessed the G6-P-I2-R2-C2-M2-A11-N2-T6-E2-H3 genotype constellation. Sequence analysis of the VP7 gene revealed a close phylogenetic relationship with bovine G6 strains from India, whereas, the VP4 gene segment was nearly identical to typical human P strain circulating in Bangladesh and the rest of the world. Phylogenetic analysis of the remaining nine gene segments revealed a close relatedness to either animal or animal derived human RVA strain. We speculated that, strain KH2288 was a monoreassortant between a human RVA strain and a RVA strain typically infecting member of the Artiodactyla, such as cattle, goat or sheep. To our knowledge, this is the first complete genotyping report of a naturally occurring G6P RVA strain, worldwide.