Quantitative and qualitative analysis of metabolic response at interim PET-scan combined with IPI is highly predictive of outcome in diffuse large B-cell lymphoma
Nols, Nathalie × Mounier, Nicolas Bouazza, Salima Lhommel, Renaud Costantini, Sabrina Vander Borght, Thierry Vekemans, Marie-Christiane Sonet, Anne Bosly, André Michaux, Lucienne André, Marc Van Den Neste, Eric #
Harwood Academic Publishers
Leukemia & Lymphoma vol:55 issue:4 pages:773-780
ABSTRACT Prognostic value of interim (18)Fluorodeoxyglucose positron-emission tomography (i-PET) was investigated in 73 (median age 60y) diffuse large B-cell lymphoma (DLBCL) patients. I-PET was analyzed by Deauville's score (DS) and ΔSUVmax. Patients with DS of 1 to 3 demonstrated a significantly (P<.000) better outcome (median FU 2.4y) than patients with score of 4 or 5 in term of EFS (79% vs 36%), PFS (83% vs 47%), and OS (91% vs 58%). EFS (73% vs 41%), PFS (78% vs 50%), and OS (88% vs 56%), were also significantly (P .023) different between patients with ΔSUVmax > 66% or ≤ 66%. Patients (n=33) combining a favorable age-adjusted IPI (0 or 1), and a negative i-PET either by DS or ΔSUVmax criteria, showed a particularly good outcome (EFS: 85%, PFS: 88%, OS: 94%). Overall, i-PET was highly and independently predictive of any outcome, and its negative predictive value was improved by combination with IPI.