The development of a clinical screening instrument for tumour predisposition syndromes in childhood cancer patients
Hopman, Saskia M J × Merks, Johannes H M de Borgie, Corianne A J M Aalfs, Cora M Biesecker, Leslie G Cole, Trevor Eng, Charis Legius E, Eric Maher, Eamonn R van Noesel, Max M Verloes, Alain Viskochil, David H Wagner, Anja Weksberg, Rosanna Caron, Huib N Hennekam, Raoul C M #
European Journal of Cancer vol:49 issue:15 pages:3247-54
Identification of tumour predisposition syndromes in patients who have cancer in childhood is paramount for optimal care. A screening instrument that can help to identify such patients will facilitate physicians caring for children with cancer. The complete screening instrument should consist of a standardised series of pictures and a screening form for manifestations not visible in the pictures. Here we describe the development of such a screening form based on an international two-stage Delphi process and an initial validation of the complete instrument.