Title: Characterization of oligonucleotide sequence isomers in mixtures using HPLC/MS
Authors: Rozenski, Jef ×
McCloskey, JA #
Issue Date: 1999
Publisher: Marcel dekker inc
Series Title: Nucleosides nucleotides & nucleic acids vol:18 issue:6-7 pages:1539-1540
Abstract: A method is described for the analysis of mixtures containing sequence isomers of oligonucleotides. The approach consists of an electrospray ionization mass spectrometric analysis in direct combination with HPLC separation. Mass spectrometry can provide sequence information based on the fragmentation patterns of oligonucleotides allowing the simultaneous characterization of sequence isomers. An example is shown for the characterization of a mixture of dCAGT, dCGTA, dTCAG, dAGTC and dTCGA.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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