Title: Synthesis, radio-LC-MS analysis and biodistribution in mice of (99)mTc-NIM-BAT
Authors: Bormans, Guy ×
Cleynhens, Bernard
de Groot, TJ
Mortelmans, Luc
Moretti, JL
Verbruggen, Alfons #
Issue Date: May-2003
Publisher: John wiley & sons ltd
Series Title: Journal of labelled compounds & radiopharmaceuticals vol:46 issue:6 pages:575-585
Abstract: S,S'-bis-trityl-N-BOC-1,2-ethylenedicysteamine (S,S'-bis-trityl-N-BOC-BAT) was conjugated to 2-nitroimidazole (NIM) through a propylene spacer in order to provide a precursor for a potential technetium-99m labelled hypoxia tracer. For labelling with technetium-99m, a two-step one-pot procedure was developed consisting of deprotection of the ligand by heating in mild acidic conditions and subsequent exchange labelling in the presence of SnCl2, tartrate and (TcO4-)-Tc-99m.
ISSN: 0362-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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