ITEM METADATA RECORD
Title: Synthesis of N-(2-[F-18]fluoroethyl)-N '-methylthiourea: a hydrogen peroxide scavenger
Authors: Gilissen, C ×
Bormans, Guy
de Groot, Tjibbe
Verbruggen, Alfons #
Issue Date: Jun-1998
Publisher: John wiley & sons ltd
Series Title: Journal of labelled compounds & radiopharmaceuticals vol:41 issue:6 pages:491-502
Abstract: N-(2-[F-18]fluoroethyl)-N'-methylthiourea ([F-18]FEMTU), a fluorine-18 labelled derivative of the hydrogen peroxide scavenger dimethylthiourea (DMTU), has been synthesized by reaction of 2-[F-18]fluoroethylamine with methylisothiocyanate. 2-[F-18]Fluoroethylamine was obtained in modest radiochemical yields (39+/-6%, mean+/-sd, n=5, decay corrected) by nucleophilic substitution with [F-18]fluoride on N-[2(p-toluenesulfonyloxy)ethyl] phthalimide followed by deprotection with hydrazine and distillation.
URI: 
ISSN: 0362-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science