Title: Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race
Authors: Vanaerschot, Manu ×
Huijben, Silvie
Van den Broeck, Frederik
Dujardin, Jean-Claude #
Issue Date: Jan-2014
Publisher: Published by Elsevier Science Publishers on behalf of the Federation of European Microbiological Societies
Series Title: FEMS Microbiology Reviews vol:38 issue:1 pages:41-55
Article number: 10.1111/1574-6976.12032
Abstract: Drug-resistant pathogens emerge faster than new drugs come out of drug discovery pipelines. Current and future drug options should therefore be better protected, requiring a clear understanding of the factors that contribute to the natural history of drug resistance. Although many of these factors are relatively well understood for most bacteria, this proves to be more complex for vectorborne parasites. In this review, we discuss considering three key models (Plasmodium, Leishmania and Schistosoma) how drug resistance can emerge, spread and persist. We demonstrate a multiplicity of scenarios, clearly resulting from the biological diversity of the different organisms, but also from the different modes of action of the drugs used, the specific within- and between-host ecology of the parasites, and environmental factors that may have direct or indirect effects. We conclude that integrated control of drug-resistant vectorborne parasites is not dependent upon chemotherapy only, but also requires a better insight into the ecology of these parasites and how their transmission can be impaired.
ISSN: 0168-6445
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Ecology, Evolution and Biodiversity Conservation Section
× corresponding author
# (joint) last author

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