Title: Potentiation of antibiofilm activity of amphotericin B by superoxide dismutase inhibition
Authors: De Brucker, Katrijn *
Bink, Anna *
Meert, Els
Cammue, Bruno ×
Thevissen, Karin #
Issue Date: 2013
Publisher: Landes Bioscience
Series Title: Oxidative Medicine and Cellular Longevity issue:2013 pages:704654-704654
Abstract: This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB). Co-incubation of C. albicans biofilms with AmB and the Sod inhibitors N,N’-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC or ATM alone. Hence, Sod inhibitors can be used to potentiate the activity of AmB against C. albicans biofilms.
ISSN: 1942-0900
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
* (joint) first author
× corresponding author
# (joint) last author

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