Title: Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial
Authors: Arshad, Freeha ×
Ickx, Brigitte
van Beem, Rachel T
Polak, Wojciech
Grüne, Frank
Nevens, Frederik
Ilmakunnas, Minna
Koivusalo, Anna-Maria
Isoniemi, Helena
Strengers, Paul F W
Groen, Henk
Hendriks, Herman G D
Lisman, Ton
Pirenne, Jacques
Porte, Robert J #
Issue Date: 2013
Publisher: BioMed Central
Series Title: BMC Surgery vol:13 pages:22
Article number: 10.1186/1471-2482-13-22
Abstract: In patients with cirrhosis, the synthesis of coagulation factors can fall short, reflected by a prolonged prothrombin time. Although anticoagulants factors are decreased as well, blood loss during orthotopic liver transplantation can still be excessive. Blood loss during orthotopic liver transplantation is currently managed by transfusion of red blood cell concentrates, platelet concentrates, fresh frozen plasma, and fibrinogen concentrate. Transfusion of these products may paradoxically result in an increased bleeding tendency due to aggravated portal hypertension. The hemostatic effect of these products may therefore be overshadowed by bleeding complications due to volume overload.In contrast to these transfusion products, prothrombin complex concentrate is a low-volume highly purified concentrate, containing the four vitamin K dependent coagulation factors. Previous studies have suggested that administration of prothrombin complex concentrate is an effective method to normalize a prolonged prothrombin time in patients with liver cirrhosis. We aim to investigate whether the pre-operative administration of prothrombin complex concentrate in patients undergoing liver transplantation for end-stage liver cirrhosis, is a safe and effective method to reduce perioperative blood loss and transfusion requirements.
ISSN: 1471-2482
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science