Title: Vitamin D in thyroid tumorigenesis and development
Authors: Clinckspoor, Isabelle
Verlinden, Lieve
Mathieu, Chantal
Bouillon, Roger
Verstuyf, Annemieke
Decallonne, Brigitte # ×
Issue Date: Aug-2013
Publisher: G. Fischer
Series Title: Progress in Histochemistry and Cytochemistry vol:48 issue:2 pages:65-98
Article number: 10.1016/j.proghi.2013.07.001
Abstract: Besides its classical role in bone and calcium homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has many non-classical effects; antiproliferative, anti-apoptotic and prodifferentiating effects of 1,25(OH)2D3 have been described in several tumour types in preclinical models. This review focuses on the insights gained in the elucidation of the role of 1,25(OH)2D3 in the normal thyroid and in the pathogenesis, progression and treatment of thyroid cancer, the most common endocrine malignancy. An increasing amount of observations points towards a role for impaired 1,25(OH)2D3-VDR signalling in the occurrence and progression of thyroid cancer, and a potential for structural analogues in the multimodal treatment of dedifferentiated iodine-resistant thyroid cancer. A role for vitamin D in thyroid-related autoimmunity is less convincing and needs further study. Altered 1,25(OH)2D3-VDR signalling does not influence normal thyroid development nor thyrocyte function, but does affect C-cell function, at least in rodents. If these findings also apply to humans deserves further study.
ISSN: 0079-6336
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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