Title: Intracellular Ca2+ signaling. A novel player in the canonical mTOR-controlled autophagy pathway
Authors: Decuypere, Jean-Paul
Paudel, Ram Chandra
Parys, Jan #
Bultynck, Geert # ×
Issue Date: Sep-2013
Publisher: Landes Bioscience
Series Title: Communicative & Integrative Biology vol:6 issue:5 pages:e25429 (4 pages)
Article number: e25429
Abstract: Functional intracellular Ca2+ signaling is essential for the upregulation of the canonical mTOR-controlled autophagy
pathway triggered by rapamycin or by nutrient deprivation. Moreover, modifications in the Ca2+-signaling machinery
coincide with autophagy stimulation. This results in enhanced intracellular Ca2+ signaling essential for driving the autophagy process. Yet, the mechanisms upstream (the players causing the changes in Ca2+ signaling) and downstream (the targets of the altered Ca2+ signals) of this Ca2+-dependent autophagy pathway remain elusive. Here, we speculate about these mechanisms based on our current knowledge.
ISSN: 1942-0889
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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