Title: Separation of oxytetracycline and its related substances by capillary electrophoresis
Authors: Li, YM ×
Van Schepdael, Ann
Roets, Eugene
Hoogmartens, Jos #
Issue Date: 1997
Publisher: Marcel dekker inc
Series Title: Journal of liquid chromatography & related technologies vol:20 issue:2 pages:273-282
Abstract: A method is described for separation of oxytetracycline and its related substances by capillary electrophoresis. Oxytetracycline is a broad spectrum antibiotic obtained by biosynthesis. Main related substances are 4-epioxytetracycline, alpha-apooxytetracycline, beta-apooxytetracycline, anhydrooxytetracycline, 2-acetyl-2-decarboxamidooxytetracycline tetracycline, 4-epitetracycline and terrinolide. Method development was undertaken with a mixture consisting of oxytetracycline and its related substances mentioned. Using an uncoated fused silica capillary, the influence of buffer pH and its concentration was systematically investigated. Non-ionic surfactant Triton X-100 was added to the running buffer for improving separation selectivity. Quantitative data are reported and compared with those of liquid chromatography and capillary zone electrophoresis.
ISSN: 1082-6076
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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