Title: Synthesis of oligoribonucleotides containing pyrimidine 2 '-O-[(hydroxyalkoxy)methyl]ribonucleosides
Authors: Bobkov, GV
Brilliantov, C
Mikhailov, SN ×
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 2006
Publisher: Inst organic chem and biochem
Series Title: Collection of Czechoslovak Chemical Communications vol:71 issue:6 pages:804-819
Abstract: A simple and efficient method for the preparation of pyrimidine 2'-O-[(2-hydroxyethoxy) methyl]ribonucleosides and 2'-O-[(3-hydroxypropoxy)methyl]ribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes.
ISSN: 0010-0765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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