Title: Conformational analysis, solvent-accessible surface and geometric extent of inhibitors and substrates
Authors: Froeyen, Mathy ×
De Winter, H
Herdewijn, Piet #
Issue Date: 2006
Publisher: Inst organic chem and biochem
Series Title: Collection of Czechoslovak Chemical Communications vol:71 issue:6 pages:842-858
Abstract: Peptide ligands are known to often bind in an extended conformation to maximize the contact surface with the receptor. The complementarity of shape and surface is a very important factor contributing to the stability of a ligand receptor complex. In this communication we try to answer the following questions: What is the influence of conformation on the surface area? Do ligands maximize their contact surface with the receptor to increase stability of the complex?
ISSN: 0010-0765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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