Title: Selecting and characterizing drug-resistant hepatitis C virus replicon
Authors: Vliegen, Inge ×
Delang, Leen
Neyts, Johan #
Issue Date: Jun-2013
Series Title: Methods in Molecular Biology vol:1030 pages:93-103
Article number: 10.1007/978-1-62703-484-5_8
Abstract: The current standard of care (SOC) for hepatitis C virus (HCV) genotype 1-infected patients consists of telaprevir or boceprevir in addition to pegylated interferon and ribavirin treatment. Other selective inhibitors of HCV replication are being developed. Drug pressure may, depending on the class of inhibitors, (rapidly) select for drug-resistant variants. Here we describe four different approaches to select in vitro for drug-resistant HCV subgenomic replicons.
ISSN: 1064-3745
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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