Title: Formation of trisaccharide nucleosides during disaccharide nucleoside synthesis
Authors: Mikhailov, SN ×
Rodionov, AA
Efimtseva, EV
Ermolinsky, BS
Fomitcheva, MV
Padyukova, NS
Rothenbacher, K
Lescrinier, Eveline
Herdewijn, Piet #
Issue Date: Oct-1998
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:10 pages:2193-2199
Abstract: The unexpected formation of trisaccharide nucleosides during synthesis of disaccharide nucleosides with a purine base moiety has been observed. The occurrence of this side reaction can be explained in terms of the instability of the protected purine nucleosides in the presence of Lewis acids. The formation of these by-products can be avoided by using the 2,3-O-isopropylidene group instead of acyl groups for the blocking of the secondary hydroxyl groups of the nucleoside.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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