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Title: BACE1 Levels Correlate With Phospho-Tau Levels In Human Cerebrospinal Fluid
Authors: Lourenco Barao, Soraia BarĂ£o
Zhou, Lujia
Adamczuk, Kate
Vanhoutvin, Tine
Van Leuven, Fred
Demedts, David
Vijverman, A-C
Bossuyt, Xavier
Vandenberghe, Rik
De Strooper, Bart # ×
Issue Date: Sep-2013
Publisher: Bentham Science Publishers
Series Title: Current Alzheimer research vol:10 issue:7 pages:671-8
Abstract: Previous studies have investigated the activity and protein levels of BACE1, the β-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.
ISSN: 1567-2050
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for the Research of Neurodegenerative Diseases
Laboratory of Neuronal Communication
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory for Cognitive Neurology
× corresponding author
# (joint) last author

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